Abstract
The purine nucleoside adenosine, which is involved in several physiological functions, regulates a variety of immune and inflammatory responses and acts as modulator of gut functions. Although it is present at low concentrations in the extracellular space, stressful conditions, such as inflammation can markedly increase its extracellular level up to micromolar range. Recent evidence suggests a prominent role of A2A receptors (A2AR) in the anti-inflammatory effect of herbal preparations as e.g. in STW 5 (Iberogast®). In the current study we investigated the role of A2AR and A2BR to regulate contractility in untreated and inflamed rat colon preparations using specific receptor agonists and antagonists.
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