Adenosine deaminase normalizes cyclic AMP responses of hypothyroid rat fat cells to forskolin, but not β-adrenergic agonists

Abstract

Lipolysis and cyclic AMP accumulation in response to β-adrenergic agonists or forskolin are severely impaired in fat cells from the hypothyroid rat. Incubating hypothyroid rat fat cells with adenosine deaminase normalizes the cyclic AMP response to forskolin, but not to β-adrenergic agonists. Increased sensitivity to adenosine action in the hypothyroid state appears to be the basis for the impaired cyclic AMP response to forskolin, but does not appear to be the underlying defect responsible for the impaired response to β-adrenergic agonists.