Abstract
Periodontitis is an unpleasant clinical condition in which an exaggerated inflammatory reaction occurs in the extravascular gingival tissue. Inflammatory cells release cytokines that amplify tissue inflammation and create the condition for periodontal tissue damage. Adenosine is a mediator that is released under several pathological conditions including ischemia and inflammation and participates in the regulation of inflammatory reaction. Among the several adenosine receptors, the adenosine A<sub>2A</sub> subtype plays a key role in resolving gingival inflammation and in protecting the periodontal tissues from damage. PDRN (polydeoxyribonuclotide) binds selectively the A<sub>2A</sub> subtype and exerts curative effect, suggesting that adenosine A<sub>2A</sub> receptor stimulation might be an innovative strategy for the treatment of periodontitis.
Highlights
Periodontitis is common diseases of the oral cavity [1]
Among the several adenosine receptors, the adenosine A2A subtype plays a key role in resolving gingival inflammation and in protecting the periodontal tissues from damage
PDRN binds selectively the A2A subtype and exerts curative effect, suggesting that adenosine A2A receptor stimulation might be an innovative strategy for the treatment of periodontitis
Summary
Periodontitis is common diseases of the oral cavity [1]. It is a devastating inflammatory condition that takes place at the level of the soft and hard tissues surrounding the teeth [2] and it is one of the leading cause of teeth loss worldwide [3]. Periodontitis is an unpleasant clinical condition in which an exaggerated inflammatory reaction occurs in the extravascular gingival tissue. Inflammatory cells release cytokines that amplify tissue inflammation and create the condition for periodontal tissue damage.
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