Abstract
Adenosine: a selfish-immunity signal?
Highlights
It is long known that immune response is energydemanding
We demonstrated that a systemic metabolic switch, which included a suppression of development and energy storage, was required for the rapid production of lamellocytes and for the effective immune response
We further showed that lamellocytes precursors released adenosine that suppressed the consumption of glucose by non-immune tissues and slowed down the host development
Summary
It is long known that immune response is energydemanding. It has become clear in recent years [1] that pretty much any immune cell in our body undergoes, upon its activation, a metabolic shift resembling the Warburg effect originally described for cancer cells. Increased energy consumption by immune cells requires a metabolic adaptation of the whole organism.
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