Abstract
The role of cAMP in the inhibitory effect of epinephrine on insulin secretion was studied by comparing the dose-response relationships of the effects of epinephrine on insulin release and [3H]cAMP content in rat pancreatic islets prelabeled with [2-3H]adenine and stimulated by various agents in vitro. Glucagon-stimulated insulin release and increased [3H]cAMP in islets were inhibited in a parallel dosedependent fashion by epinephrine. In contrast, glucosestimulated insulin release was more sensitve to inhibition by epinephrine than was glucose-induced [3H]- cAMP accumulation. Thus, 3 × 10-8 M epinephrine produced 50% inhibition of the insulin release stimulated by 26.7 tnM glucose, whereas 10-6 M epinephrine was required to produce 50% inhibition of the [3H]cAMP response to glucose. In contrast to the inhibitory effects of a high concentration of epinephrine (10-6 M) on glucagon and glucose-stimulated increases in islet [3H]cAMP, this concentration of epinephrine did not decrease the increased [3H]cAMP le...
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