Adenomatous Hyperplasia Mimicking Adenocarcinoma of the Gallbladder – Diagnostic Dilemma Resolved with Immunohistochemistry: A Case Report with Review of Literature

Abstract

Adenomatous hyperplasia (AH) of the gallbladder is an uncommon and unique entity. AH is commonly confused with malignant GB neoplasms in the setting of chronic cholecystitis, gallstones or cholesterolosis. We herein report a case of AH with deep seated RA sinuses mimicking gallbladder cancer in a middle-aged female in the setting of symptomatic cholecystitis with cholelithiasis and cholesterolosis. In our case microscopy showed diffuse villous type of mucosal hyperplasia with proliferative, bland looking densely packed glands with numerous closely opposed R-A sinuses extending upto the peri muscular connective tissue. The whole microscopic picture closely simulating a well differentiated gall bladder carcinoma (GBC), hence warranted use of IHC to resolve the dilemma and to reach a definitive diagnosis. A literature search yields minimal information on these benign entities, thus suggesting the infrequency of its reporting, hence the need for this case report.