Abstract
Adenoid Cystic Carcinoma (ACC) is an uncommon lesion of the salivary glands composed of modified myoepithelial and ductal cells. Conventional histopathologic examination is the main tool for diagnosis, although in some cases immunohistochemical analysis is necessary. The present report describes a case of ACC with unusual histopathologic appearance and immunohistochemical markers used as auxiliary tool for the diagnosis. A 67-year-old female patient displaying nodular and erythematous lesion localized in the left ventral surface of the tongue. On suspicion of epidermoid carcinoma, incisional biopsy was performed. The histopathologic examination showed small nests of cells with squamous malignant characteristics exhibiting exclusively solid pattern with muscular and neural invasion. The immunohistochemical test proved positive for the following markers p53, 34β12, CK5/6, EMA, CK14, S-100 and c-Kit, which are characteristic of ACC. The patient underwent hemiglossectomy and supraomohyoid left empty. Currently, the patient is being observed and there is no recurrence of the lesion.
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