Abstract
Adenoid basal carcinoma of the uterine cervix is a rare low-grade tumor and its cell origin is still obscure. Adenoid basal carcinoma can be confused with adenoid basal hyperplasia, adenoid cystic carcinoma, and basaloid squamous cell carcinoma of the cervix. We present here a case of a 59 year-old-female who initially presented with a high-grade squamous intraepithelial lesion on Pap smear. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology revealed focal invasive adenoid basal carcinoma with extensive areas of a high-grade squamous intraepithelial lesion involving the endocervical gland. The immunohistochemical stain was positive for p16.
Highlights
Adenoid basal carcinoma (ABC) of the cervix is a rare neoplasm with fewer than 100 reported cases and the majority occur in the 5th decade or older with a predilection for postmenopausal non-Caucasian women.[1]
Adenoid basal carcinoma is postulated to be derived from the multipotential basal or reserve cell layer of the cervical epithelium[3], but this has not been confirmed
Small islands of basaloid squamous cell carcinoma may be composed of variably sized nests of relatively small, hyperchromatic tumor cells, which may mimic adenoid basal carcinoma (ABC) and smaller ABC-like nests
Summary
Adenoid basal carcinoma (ABC) of the cervix is a rare neoplasm with fewer than 100 reported cases and the majority occur in the 5th decade or older with a predilection for postmenopausal non-Caucasian women.[1]. The prognosis is usually favorable; this carcinoma must be distinguished from the more aggressive adenoid cystic carcinoma and basaloid squamous cell carcinoma of the uterine cervix, which is sometimes very similar histologically. We report a case of adenoid basal carcinoma of the cervix discovered incidentally in a patient with HSIL.
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