Abstract
BackgroundAccording to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Due to its rarity, no study investigating the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC has been reported.MethodsSixty eight patients who underwent surgical resection for lung adenosquamous carcinoma in our institute between January 2006 and March 2017 were retrospectively reviewed. Data regarding the clinical features, radiologic findings and prognosis characteristics were collected.ResultsThirty nine patients of the study cohort were with AC-predominant ASC and 29 with SCC-predominant ASC. There was no significant difference between the two subgroups in age, gender, smoking history, serum carcinoembryonic antigen (CEA) level and T,N classification. Air bronchogram was found more frequently in AC-predominant ASC than in SCC-predominant ASC (P = 0.046). Multivariate analysis identified pathological subtype (P = 0.022) and CT findings of peripheral location (P = 0.009) to be independent prognostic factors.ConclusionsAC-predominant ASC were more commonly presented with air bronchogram, and were with a better prognosis than SCC-predominant ASC.
Highlights
According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes
Complete tumor resection with hilar mediastinal lymphadenectomy was accomplished in all patients
Our findings observed that: (1) ASC tended to have clinical characteristics of both adenocarcinoma and squamous cell carcinoma with poorer prognosis; (2) ASC could be divided into ACpredominant and SCC-predominant according to pathological subtypes, AC-predominant ASC were more commonly presented with air bronchogram and were with a better prognosis than SCC-predominant ASC; (3) Peripheral location of ASC served as an independent good prognostic factor
Summary
According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. No study investigating the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC has been reported. According to the proportion of glandular and squamous components, ASC could be divided into AC and SCC predominant. Due to its rarity, no definitive clinical conclusion have been reached and to the best of our knowledge, there has been no report regarding radiologic findings of ASC with different predominant subtypes. In this study we further explored the impact of different subtypes on the clinical features, radiologic findings and prognosis characteristics of ASC
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