Abstract
BackgroundThe incidence of adenocarcinoma of the esophagogastric junction is increasing. This study aims to evaluate the clinicopathological features of Chinese patients with adenocarcinoma of the esophagogastric junction and to define prognostic factors.MethodsWe retrospectively reviewed a database of 382 consecutive patients with adenocarcinoma of the esophagogastric junction at the First Affiliated Hospital of Xi’an Jiaotong University from January 2005 to March 2010. All patients were classified according to the Siewert’s classification and staged according to the latest edition of the American Joint Committee on Cancer categories.ResultsSix of the 382 patients had type I adenocarcinoma, 220 had type II, and 156 had type III. There was no significant difference in the overall survival of different Siewert subtypes. According to the multivariate analysis, pathological lymph node stage, age, and the existence of lymphovascular invasion were the independent factors of prognosis of adenocarcinoma of the esophagogastric junction following surgery.ConclusionsOn the data, the distribution of the three types of tumor was found to be different from that reported in Western countries. Lymph node metastasis, lymphovascular invasion, and age were significant and independent factors for poor prognosis after R0 resection for adenocarcinoma of the esophagogastric junction.
Highlights
The incidence of adenocarcinoma of the esophagogastric junction is increasing
The current International Union against Cancer (UICC) TNM classification of malignant tumors is the first to define the classification of adenocarcinomas of the esophagogastric junction
Patients We retrospectively reviewed a database of 382 consecutive patients of distal esophageal adenocarcinoma, adenocarcinoma of the cardia, and proximal gastric adenocarcinomas at the First Affiliated Hospital of Xi’an Jiaotong University from January 2005 to March 2010
Summary
The incidence of adenocarcinoma of the esophagogastric junction is increasing. This study aims to evaluate the clinicopathological features of Chinese patients with adenocarcinoma of the esophagogastric junction and to define prognostic factors. In Western countries, there has been a dramatic increase in the incidence of adenocarcinomas of the esophagogastric junction (AEG). The current International Union against Cancer (UICC) TNM classification of malignant tumors is the first to define the classification of adenocarcinomas of the esophagogastric junction. According to the UICC, a tumor with an epicenter within 5 cm of the esophagogastric junction (EGJ) and extension into the esophagus, is classified and staged according to the esophageal scheme. Tumors with an epicenter greater than 5 cm from the EGJ or those within 5 cm of the EGJ without extension into the esophagus were staged using the gastric carcinoma scheme [5].
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