Adenocarcinoma with Minimal Deviation of the Cervix: What Management?

Al Moubaker H

doi:10.4172/2161-0932.1000148

Abstract

The cervix adenocarcinoma results in an average 15% of cervical carcinomas. It is most often associated with infection with HPV type 16 or 18. Screening has its particularities compared to squamous cell carcinoma. The minimal deviation adenocarcinoma is a rare histological entity of cervix adenocarcinoma. Cervical cytology provides an imperfect diagnosis of glandular cells compared to squamous lesions, although the 2001 Bethesda system still allows a better management of patients with abnormal glandular cells; the diagnosis is based on histological study. We report a case of 46 years-old woman that was treated for minimal deviation adenocarcinoma of the cervix. It is likely that in future, the screening either cytological or viral must be completed by a specific molecular marker of these lesions.

Highlights

The minimal deviation adenocarcinoma was described in 1975 by a gynecologist as “malignant adenoma”.In 2003, the WHO has defined it as endocervical adenocarcinoma mucinous, well differentiated, consisting of an endocervical glandular hyperplasia of lobular architecture resembling glands but with the characteristics of adenocarcinoma [1].It is associated in 10 to 15% with Peutz-Jeghers syndrome, and frequently Lobular Endocervical Glandular Hyperplasia (LEGH)
Surgical treatment was offered to the patient who received a total hysterectomy adnexal inter-vaginally, the pathological results returned for minimal deviation adenocarcinoma of the cervix with simple hyperplasia of the endometrium without atypia
Well-differentiated mucinous endocervix adenocarcinomas correspond to 70% of endocervix adenocarcinomas [2]

Summary

The cervix adenocarcinoma results in an average 15% of cervical carcinomas. It is most often associated with infection with HPV type 16 or 18. Screening has its particularities compared to squamous cell carcinoma. The minimal deviation adenocarcinoma is a rare histological entity of cervix adenocarcinoma. Cervical cytology provides an imperfect diagnosis of glandular cells compared to squamous lesions, the 2001 Bethesda system still allows a better management of patients with abnormal glandular cells; the diagnosis is based on histological study. We report a case of 46 years-old woman that was treated for minimal deviation adenocarcinoma of the cervix. It is likely that in future, the screening either cytological or viral must be completed by a specific molecular marker of these lesions

Introduction

Findings

Discussion

Conclusion