Abstract
This image shows colon adenocarcinoma in the cecum. Which statement about colorectal adenocarcinomas is most accurate?a.Only sporadic colorectal adenocarcinomas can be associated with microsatellite instabilityb.Only colorectal carcinomas associated with the Lynch syndrome (hereditary nonpolyposis colorectal carcinoma) are associated with microsatellite instabilityc.Colorectal carcinomas are the only carcinomas associated with microsatellite instabilityd.Carcinomas of various sites—colon, rectum, and endometrium among others—can have microsatellite instability Answer: d. Carcinomas of various sites—colon, rectum, and endometrium among others—can have microsatellite instability.1Chang L. Chang M. Chang H.M. Chang F. Microsatellite instability: a predictive biomarker for cancer immunotherapy.Appl Immunohistochem Mol Morphol. 2018; 26: e15-e21Crossref PubMed Scopus (187) Google Scholar Microsatellite instability is a characteristic feature of the Lynch syndrome (hereditary nonpolyposis colorectal carcinoma) but can also occur somatically in sporadic colorectal carcinomas.1Chang L. Chang M. Chang H.M. Chang F. Microsatellite instability: a predictive biomarker for cancer immunotherapy.Appl Immunohistochem Mol Morphol. 2018; 26: e15-e21Crossref PubMed Scopus (187) Google Scholar
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