Abstract
Lambert-Eaton myasthenic syndrome (LEMS) is a paraneoplastic neuromuscular junction disorder. LEMS presents with muscular weakness and fatigability, mainly involving the proximal lower limbs. There are 2 types of LEMS depending on the etiology: paraneoplastic and idiopathic. The paraneoplastic form, which constitutes more than a half of the cases, is mostly associated with intrathoracic neoplasms. Most cases are seen in patients with small cell lung cancer; other subtypes of lung cancer are extremely rare. In this article, we report a case of LEMS as a rare association with adenocarcinoma of the lung.
Highlights
Lambert-Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic disorder of neuromuscular junction (NMJ), characterized by muscle weakness and fatigability, mainly involving the proximal lower limbs
We report a rare case of LEMS associated with adenocarcinoma of the lung
Lambert-Eaton myasthenic syndrome was first described as a paraneoplastic syndrome in patients with lung cancer, known to be idiopathic in nearly half the cases.[6]
Summary
Lambert-Eaton myasthenic syndrome (LEMS) is a rare paraneoplastic disorder of neuromuscular junction (NMJ), characterized by muscle weakness and fatigability, mainly involving the proximal lower limbs. Vital signs were the following: blood pressure of 139/79 mm Hg, pulse rate of 85 beats per minutes, respiratory rate of 17 breaths per minute, temperature of 98.6°F, and an oxygen saturation of 99% on room air. She was alert and oriented to person, place, and time. Pertinent positive findings on neurological examination showed motor weakness of her lower extremities muscle with power of 3 out of 5 in her proximal lower extremities’ muscles.
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