Abstract
BackgroundIn view of the rarity of vaginal agenesis, malignancy arising in the neovagina is extremely rare.Case presentationHere, we report a 76-year-old female with an adenocarcinoma arising in the sigmoid colon neovagina which was constructed 53 years ago for congenital vaginal agenesis. Vaginal endoscopy to examine vaginal bleeding revealed a protruding lesion occupying three quarters of the lumen in the vicinity of anastomosis of the residual vagina and sigmoid colon. Transvaginal ultrasonography revealed the muscularis propria layer (hypoechoic fourth layer) to be interrupted. CT revealed no distant metastasis. Total pelvic exenteration was performed based on the diagnosis of neovaginal cancer at the anastomosis site. The 45-mm tumor showed well-differentiated adenocarcinoma with a mucinous adenocarcinoma component. Immunohistochemistry showed no p16-overexpressing tumor cells, suggesting the lack of human papilloma virus infection.ConclusionsAlthough rare, clinicians should be aware of cancer that arises in the ectopic intestine when anastomosed with other organs.
Highlights
In view of the rarity of vaginal agenesis, malignancy arising in the neovagina is extremely rare.Case presentation: Here, we report a 76-year-old female with an adenocarcinoma arising in the sigmoid colon neovagina which was constructed 53 years ago for congenital vaginal agenesis
Neovaginal construction/reconstruction is indicated for cases of congenital vaginal agenesis which is an uncommon genital tract anomaly that is reported to occur in 1 per 4000–5000 newborn females [1, 2], as well as genetic sexual ambiguity, vaginal loss resulting from gynecologic cancer, or post-traumatic injury and male to female transsexualism [3, 4]
* Correspondence: kazunosukefukudai@yahoo.co.jp 1Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 1040045, Japan Full list of author information is available at the end of the article vaginal agenesis, malignancy arising in the neovagina is extremely rare
Summary
In view of the rarity of vaginal agenesis, malignancy arising in the neovagina is extremely rare.Case presentation: Here, we report a 76-year-old female with an adenocarcinoma arising in the sigmoid colon neovagina which was constructed 53 years ago for congenital vaginal agenesis. Conclusions: rare, clinicians should be aware of cancer that arises in the ectopic intestine when anastomosed with other organs. * Correspondence: kazunosukefukudai@yahoo.co.jp 1Department of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-ku, Tokyo 1040045, Japan Full list of author information is available at the end of the article vaginal agenesis, malignancy arising in the neovagina is extremely rare.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
