Abstract
Adenine nucleotides (ADP>ATP) greatly enhance Ca 2+ uptake and retention in rat brain mitochondria. In the presence of both spermine and ADP, brain mitochondria sequester Ca 2+ down to cellular free Ca 2+ levels, suggesting a role for mitochondria in modulating Ca 2+ cycles in brain cells. Analysis of the effects of various inhibitors on Ca 2+ uptake and efflux suggest that locking the ADP/ATP translocator in its M-state stimulates electrogenic Ca 2+ uptake and, to a lesser extent, inhibits Ca 2+ efflux. It is suggested that this effect is due to a modulation of the surface charge on the M-side which enhances Ca 2+ dissociation from the carriers.
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