Abstract
Adenine prevents the down-regulation of DNA synthesis in gamma -irradiated EAT and HL60 cells. This protective effect is related to the initiation of DNA replication. The effectiveness of this protection increases with the concentration of adenine in both cell lines. The maximum protective effect of adenine induced in EAT cells occurs at about 10 times lower concentration as compared with HL60 cells; however, the level of this effect is almost the same in both cell lines. The results indicate that the prevention of the down-regulation of DNA synthesis in gamma -irradiated EAT and HL60 cells is conditioned mainly by the arrest of the cells in the early S-phase. It is evident that DNA synthesis in cells beyond G1/S boundary is insensitive to gamma -radiation.
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