Abstract
Detection of biological samples in low concentration is of great significance to the basic research in science, the development of medical technology and many other fields related to our lives. Surface-Enhanced Raman Scattering (SERS), well-known as a powerful analytical tool with high sensitivity, is especially suitable for biomolecule detection as it enables near infrared (NIR) excitation and label-free detection. SERS probe made of conventional optical fiber provides better flexibility in detection; however, it requires a complicated fabrication process and doesn't serve as a well-set detecting platform. In this talk we propose and demonstrate a photonic crystal fiber (PCF) based SERS probe, which has the new advantages of simplicity in fabrication, better light confinement and increased light-analyte interaction volume. The PCF-based SERS probes are prepared in three different ways: mixed solution of sample and gold nanoparticles filled in air holes of PCF, sample solution dried in gold coated air holes and sample solution filled in gold coated air holes, respectively. Sample solution of adenine is in concentration of about 10-6M. Almost every characteristic peak of adenine can be observed in the spectra detected by each of the three probes.© (2007) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.
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