Abstract
Adducin is a membrane-skeletal protein localized at spectrin-actin junctions, involving in the formation of the network of cytoskeleton, cellular signal transduction, ionic transportation, cell motility and cell proliferation. While previous researches focused mainly on the relationship between adducin and hypertension, there are few studies focusing on the role of adducin in tumor. Previous studies showed that adducin played a role in the evolution and progression of neoplasm. This review makes a brief summary on the structure, function and mechanism of adducin and how adducin functions in tumorigenesis and metastasis.
Highlights
Adducin is a ubiquitously expressed membraneskeletal protein, which was firstly extracted from human erythrocyte in 1986 [1]
Previous studies reported that adducin showed an abnormal level of expression or unusual phosphorylation in some tumors, suggesting that adducin may play a role in the evolution and progression in tumors
Human ADD2 is localized at chromosome 2p13-p14 [5], whereas ADD3 is on chromosome 10q24.2-24.3[6]
Summary
Adducin is a ubiquitously expressed membraneskeletal protein, which was firstly extracted from human erythrocyte in 1986 [1]. In 1991, Joshi and Gilligan found two adducin subunits named α adducin (ADD1) and β adducin (ADD2) [2], respectively. In 1995, Dong et al, reported the existence of γ adducin (ADD3) [3]. Adducin can be phosphorylated by PKA, PKC, and Rho-kinase. It can bind to Ca2+/Calmodulin to exert functions. There is no doubt that abnormal phosphoadducin will disturb its function in cell proliferation, motility and signaling. Previous studies reported that adducin showed an abnormal level of expression or unusual phosphorylation in some tumors, suggesting that adducin may play a role in the evolution and progression in tumors
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