Abstract
It is increasingly evident that glycated haemoglobin, fasting plasma glucose and postprandial glucose — the classical static parameters of glycaemic control — insufficiently reflect glycaemic variability. Other parameters such as mean glucose value and glycaemic swing offer valuable insights but glycaemic variability is complex. Even frequent self-monitoring of blood glucose may not adequately reflect the presence of acute glucose fluctuations that are associated with oxidative stress and may contribute to the development of complications. To date there have been no prospective clinical studies to investigate the true risks associated with glycaemic variability, but it is clearly important to individualise treatment to maintain glycaemic control in diabetes. Based on current evidence, improved assessment of glycaemic variability may in future help to reduce the risk of harmful hypoglycaemia, improve glycaemic control and reduce the risk of complications.
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