Abstract
Simple SummaryThis technical note addresses the need to consider uncertainties when using experimental procedures to extract a geometry that is consequently used for computational simulations. Many uncertainties enter the process in both the experimental and computational techniques.Imaging subject-specific heart valve, a crucial step to its design, has experimental variables that if unaccounted for, may lead to erroneous computational analysis and geometric errors of the resulting model. Preparation methods are developed to mitigate some sources of the geometric error. However, the resulting 3D geometry often does not retain the original dimensions before excision. Inverse fluid–structure interaction analysis is used to analyze the resulting geometry and to assess the valve’s closure. Based on the resulting closure, it is determined if the geometry used can yield realistic results. If full closure is not reached, the geometry is adjusted adequately until closure is observed.
Highlights
Tae-Jin KimLeonardo da Vinci’s later work (≈1506 until his death in 1519) encompasses studies on the heart from the perspective of an architect–engineer and is permeated with recognition as to how mechanics relate to human pathology
The computational platform for establishing heart valve (HV) geometry is based on μCT datasets, followed by image processing, mesh generation and, valve closure simulation using a fluid–structure interaction (FSI) approach [8]
When the HV model is elongated in the z-direction to counteract the uncertainties, a linear relationship between the elongation and regurgitant orifice area (ROA) can be seen (Figure 4), with 30% elongation yielding healthy closure as observed in experimental settings before the exposure to the air
Summary
Leonardo da Vinci’s later work (≈1506 until his death in 1519) encompasses studies on the heart (among other organs) from the perspective of an architect–engineer and is permeated with recognition as to how mechanics relate to human pathology. With the progress of scientific research and development in the field of mechanics, we enjoy new ways to study how mechanics relate to human pathology. The urgency to continue exploring the mechanics of heart valves and new products and procedures related to their repair/replacement continues to be relevant. In vitro procedures have been developed to more accurately capture every detail These procedures, too, are associated with their own set of challenges
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