Abstract
In numerous problems where the aim is to estimate the effect of a predictor variable on a response, one can assume a monotone relationship. For example, dose-effect models in medicine are of this type. In a multiple regression setting, additive monotone regression models assume that each predictor has a monotone effect on the response. In this paper, we present an overview and comparison of very recent frequentist methods for fitting additive monotone regression models. Three of the methods we present can be used both in the high dimensional setting, where the number of parameters $p$ exceeds the number of observations $n$, and in the classical multiple setting where $1<p\leq n$. However, many of the most recent methods only apply to the classical setting. The methods are compared through simulation experiments in terms of efficiency, prediction error and variable selection properties in both settings, and they are applied to the Boston housing data. We conclude with some recommendations on when the various methods perform best.
Highlights
IntroductionEspecially in the life sciences, effects are often naturally subject to some shape restrictions, in particular monotonicity
The monotone regression methods we have considered in this overview are all non-Bayesian methods
Bornkamp and Ickstadt [7] develop a Bayesian method for univariate monotone regression, and the method is generalised to the multivariate setting in [8], for an additive monotone regression model
Summary
Especially in the life sciences, effects are often naturally subject to some shape restrictions, in particular monotonicity. In such situations, the gjs in (1.1) are assumed to be smooth and monotone functions. We will especially consider the methods developed in [11, 39, 45, 44, 25] These are all methods developed for the classical regression setting, but the method in [25] can be used in the high dimensional case. The high dimensional monotone regression methods can be used without prior information on the monotonicity direction, and can potentially be a valuable resource in the low dimensional setting
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