Additional Possibilities of Diffuse Non-toxic Goiter Therapy in Adult Patients Residing in Areas with Mild Iodine Deficiency and Anthropogenic Pollution of the Environment

Abstract

Aim: to assess the efficacy of non-toxic goiter treatment by the use of iodine alone or combinations of iodine with selenium and enterosorbent in adults on the territories of mild iodine deficiency and anthropogenic pollution. Methods: we have cared out 6-month prospective study in which 90 adults with goiter from the areas with mild iodine deficiency and anthropogenic pollution were divided into 3 groups: 30 of them took 200 mcg of KI (group 2); 30 had KI combined with enterosorbent preparation (group 3); 30 had combinations of iodine with selenium and enterosorbent given in physiological doses (group 4). Thyroid volume, status, biochemical parameters were evaluated at baseline, at 3 and 6 month of the treatment. Results were compared with those among healthy controls (n = 28, group 1). Results. The most significant decreasing of thyroid volumes and TSH was found in group 4 in 6 month compared with the baseline (11,9% and 22,6% retrospectively, р < 0,00001 for both). The changes in groups 2 and 3 were similar but less significant. Conclusions. Combined therapy can be of benefit in patients with diffuse non-toxic goiter residing in areas with mild iodine deficiency and anthropogenic pollution of the environment.