Abstract
The platelets from sixteen patients with Glanzmann's thrombasthenia have been analysed by isoelectric focusing and gradient sodium dodecyl sulphate-discontinuous polyacrylamide gel electrophoresis in a two-dimensional technique and compared with normals. As well as the previously described absence or deficiency of glycoproteins IIb and IIIa and a marked reduction in fibrinogen levels there were changes in the isoelectric point of glycoproteins Ib and IIIb and increased periodic acid-Schiff's reagent staining of some other glycoproteins. These differences imply that in Glanzmann's thrombasthenia there is more general perturbation of platelet membrane glycoproteins than previously suspected.
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