Abstract
The American Academy of Pediatrics have previously described comorbidities and health care recommendations in Down syndrome.This review was conducted of topics that have not been included in previously published recommendations or that require updating, this topics are: neonatal hyperbilirubinemia, thyroid dysfunction, deglutition disorders, immunity, vaccination, pulmonary hypertension, diabetes mellitus, dyslipidemias, hyperuricemia, vitamin D, oxidative stress, and autism. Method: Searches were performed with CINAHL, Medline, EMBASE, PsycINFO, PubMed, LILACS, RIMA and BNI and assessed for methodological quality using the Joanna Briggs Institute tool. Conclusions: The medical aspects presented in this articlecan help to the health care professionals to provide more effective care. The early detection of some comorbiditiescan improve prognosis and lower the cost of care for the complications then may cause.
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