Abstract
Backgrounds: Morus alba L. (mulberry leaf) is frequently used for therapeutic purposes in China. This study investigated the hypoglycemic and hypolipidemic effects of a reported antidiabetic herbal formula (PLCP) supplemented with mulberry leaves (MPLCP) in high-fructose- and high-fat- (HFF) fed mice. Methods: Six-week-old CD-1 male mice were fed on normal standard diet for 10 weeks. Fat emulsion with or without aqueous/ethanol extracts of PLCP/MPLCP was administrated by gavage daily for HFF groups. The normal group only received vehicle. 15% Fructose drinking water was supplied for HFF groups. Results: MPLCP was less effective than PLCP in hypoglycemic effect. The addition of mulberry leaves impeded not only the decrease in insulin resistance and serum free fatty acid content but also the increase in spleen index. The ethanol extract of MPLCP caused remarkable increase in low-density lipoprotein levels (p < 0.01) and significant increase in total cholesterol level (p < 0.05) compared with model group. Thus the effect of MPLCP was detrimental to abnormal serum lipid levels. Conclusion: The addition of mulberry leaves to PLCP weakened the hypoglycemic effects of the original formula and exacerbated dyslipidemia.
Highlights
Traditional Chinese medicines have been extensively used to prevent and treat human diseases in East Asia
In diabetic and hypercholesterolemic subjects, the supplementation of mulberry leaves can significantly reduce the levels of blood glucose, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein (LDL) cholesterol, and very low-density lipoprotein cholesterol; this supplementation can significantly increase the levels of high-density lipoprotein (HDL) cholesterol (Andallu et al, 2003)
Values are means±standard deviation (SD) (n=10), *p
Summary
Traditional Chinese medicines have been extensively used to prevent and treat human diseases in East Asia. (mulberry) is mainly found in China, Japan, and Korea, where it is frequently used as a therapeutic agent for fever, protecting the liver, and blood pressure (Venkatesh et al, 2008). It has been implicated in anti-inflammatory, anti-atherosclerosis, and anti-cancer activities (Naowaratwattana et al, 2010; Padilha et al, 2010; Sharma et al, 2010). Other bioactive ingredients of mulberry leaves have been identified including polyphenolic compounds, such as rutin, quercetin, chlorogenic acid, apigenin, and luteolin (Chu et al, 2006; Zhishen et al.1999). The effects of PLCP and MPLCP on blood glucose, blood lipid, and NAFLD were investigated using the same mouse model
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