Addition of Modified Jadad Method to Evaluate the Rationality of Over-explanatory Drug Use: Taking Naloxone as an Example

Abstract

Objective to evaluate the rationality of naloxone injection superdrug specification by evidence-based medicine and adding modified Jadad scale, and to establish the evaluation standard of rational drug use. Methods 540 medical records of naloxone used in 2019 were extracted, and the use of naloxone was analyzed. At the same time, the evidence-based medical evidence used in naloxone superscript was collected and the literature was graded by improved Jadad scale.≥4 points were used as high quality literature. Combined with evidence-based medicine and improved Jadad scale, 540 medical records with naloxone were reviewed. Results In evidence-based medical evidence collection, the guidelines for clinical treatment of craniocerebral trauma clearly put forward that naloxone injection in craniocerebral injury has a clear indication, but also given a clear dosage and course of treatment. By using the modified Jadad scale to screen and score the literature after 2013, it is determined that the coma caused by cerebral infarction is also a reasonable indication of overstatement. Combined with evidence-based medicine and improved Jadad scale method, 87.3% of the indications for the use of naloxone injection in our hospital were within the range of rational use, and the evaluation standard of rational use of naloxone was established. Conclusion: It is a new attempt to provide evidence-based basis for over-explanatory drug use through evidence-based medicine and improved Jadad scale method.