Abstract
Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al. in 2012. CS is historically associated with a poor prognosis (Marthey et al., 2014). However, histological and clinical improvements have been described in most studies with concomitant usage of corticosteroids and/or gluten-free diet (Marthey et al., 2014). We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug. The literature on this topic is briefly reviewed.
Highlights
Claudine Desruisseaux,1 Michaël Bensoussan,1 Etienne Désilets,1 Hanh-Khiem Tran,1 Robert Arcand,2 Germain Poirier,3 Andrew Wisniewski,1 and Thibaut Manière1
We report a unique case of olmesartan-induced collagenous sprue in a 79-year-old man that showed complete histological and clinical remission with the sole withdrawal of the incriminating drug
Collagenous sprue (CS) is a rare form of enteropathy that has been classically regarded as a complication of refractory celiac disease, an association that remains controversial [1]
Summary
Claudine Desruisseaux,1 Michaël Bensoussan,1 Etienne Désilets,1 Hanh-Khiem Tran,1 Robert Arcand,2 Germain Poirier,3 Andrew Wisniewski,1 and Thibaut Manière1. Collagenous sprue (CS) is a distinct clinicopathological disorder histologically defined by a thickened subepithelial band (Freeman, 2011). It is a rare condition which has been recently observed in a significant proportion of sprue-like enteropathy associated with olmesartan, a novel entity described by Rubio-Tapia et al in 2012.
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