Adding Propranolol to Topiramate is Innefective in Chronic Migraine: In Search of a Better Combination Therapy for Chronic Migraine

Abstract

Methods: This was a double-blind, placebo-controlled, randomized clinical trial conducted through the National Institute of Neurological Disorders and Stroke Clinical Research Collaboration, expected to randomize 250 chronic migraine subjects inadequately controlled (≥10 headaches/month) with topiramate (50–100 mg/day) to either propranolol LA (long acting) (240 mg/day) or placebo. Primary outcome was 28day moderate to severe headache rate reduction at 6 months (weeks 16 to 24), compared with baseline (weeks -4 to 0).