Abstract
The thrombin-induced clotting of fibrinogen does not lead to hemostasis (Duckert et al, 1960). The fibrin molecules in the clot are connected only with hydrogen bonds, and are readily dispersed in concentrated urea solutions (Laki and Lorand 1948; Laki and Chandrasekhar, 1963).It was discovered by Laki and Lorand (1948) that the intervention of a plasma component (called: Laki-Lorand Factor = LLF, Fibrin Stabilizing Factor = FSF, Fibrinase) in the presence of Ca-ions was needed to render the clot insoluble in urea solutions. The plasma component introduced bonds between the fibrin molecules so that urea could not disperse the clot. A few years ago, Lowey et al (1961) succeeded in purifying this plasma component and showed that it was an enzyme. The purpose of this communication is to show that it is now possible to describe the mechanism by which the primary bonds are introduced between the fibrin molecules.
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