Abstract
ADAR1, a promising “protecting” biomarker in oral squamous cell carcinoma
Highlights
For the analysis of ADAR1 expression, we used a tissue microarray (TMA) including 54 patients, who filled informed consent
The reaction catalyzed is a deamination of adenosine to inosine, which is read as guanosine
Above all in oral squamous cell carcinoma (OSCC), that ADAR1 increased expression in the cytoplasm is protective and influence the patients’ prognosis
Summary
For the analysis of ADAR1 expression, we used a tissue microarray (TMA) including 54 patients, who filled informed consent. Observational quantification analysis was performed by an experienced pathologist, according to two parameters: the intensity of staining and the percentage of the stained cells in both cytoplasm and nucleus. The intensity (I) of expression was scored from 0 to 3 (0 = no staining; 1 = yellow; 2=light brown; 3 = black brown/black). The proportion (%) of cells staining positively was scored from 1 to 6 (1 = 0-4%; 2 = 5-19%; 3 = 20-39%; 4 = 40-59%; 5 = 60-79%; 6 = 80-100%). Categorization of the scores in low (0-1/0-1-2-3) and high (2-3/4-5-6) intensity/percentage of positive expression for ADAR1, was undertaken in order to highlight a possible and di erent role of ADAR1 according to its allocation. SPSS 21.0 Software was used for the statistical analysis
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