Adaptogenic activity of Cinnamomum camphora, Eucalyptus globulus, Lavandula stœchas and Rosmarinus officinalis essential oil used in North-African folk medicine.

Mahieddine Boumendjel,Amel Boumendjel,Ismaïl Bouziane,Sandra Feknous,Asma Chibi,Abdennour Boucheker,Faiza Taibi,Aïssa Benselhoub,Mahfoud Messarah,Nawel Bouzeraa,Amira Taguida,Nesrine Feknous,Omar Sekiou,Azzeddine Toubal,Naouel Rekioua,Abdallah Metai,Allaeddine Baraoui,M.a Bouaziz ,H R Zaidi ,Salem N'har

doi:10.14715/cmb/2021.67.2.12

Abstract

Depressive anxiety is one of the most emotional disorders in our industrial societies. Many treatments of phobias exist and are based on plant extracts therapies, which play an important role in the amelioration of the behavior. Our study aimed to evaluate the adaptogenic activity of different essential oils provided from local plants: Cinnamomum camphora (Camphora), Eucalyptus globulus (Blue gum), Lavandula stœchas (Topped lavender) and Rosmarinus officinalis (Rosemary) on Wistar rats. The adaptogenic activity was evaluated on the elevated plus-maze. The efficacy of the extract (200 mL/kg) was compared with the standard anxiolytic drug Diazepam® 1 mg. Animals administered by the essential oil of Lavandula stœchas, Cinnamomum camphora, Rosmarinus officinalis and Eucalyptus globulus showed a behavior similar to those treated with Diazepam®. For groups treated with the following essential oils: Rosmarinus officinalis, Lavandula stoechas and Cinnamomum camphora at a dose of 200 mL/kg, we notice an increase in the time spent on the open arms of the elevated plus-maze and a decrease in time spent on the closed arms of the elevated plus-maze, especially for Rosmarinus officinalis, which explains the anxiolytic effect of these plants. We also notice a decrease in the number of entries in closed arms, open arms and the number of passing to the central square. The increase in the number of entries to open arms with Eucalyptus globulus essential oil shows a reduction in anxiety behavior in rodents and this shows that these plants have an inhibitory effect.

Highlights

The plants represent the first natural medication to consider toget out of a habitand replace chemical treatment [1]
For groups treated with the following essential oils: Rosmarinus officinalis, Lavandula stoechas and Cinnamomum camphora at a dose of 200 mL/kg, we notice an increase in the time spent on the open arms of the elevated plus-maze and a decrease in time spent on the closed arms of the elevated plus-maze, especially for Rosmarinus officinalis, which explains the anxiolytic effect of these plants
We note that the time spent on open arms is variable from one essential oil to another.The majority of oils used show a state of relaxation in the behavior of rats.As below the graph, representing the behavior of rats subjected to the Eucalyptus globulus-based treatment, we notea very highly significant difference in the behavior of rats in their displacement and the past time on open arms and closed arms

Summary

Introduction

The plants represent the first natural medication to consider toget out of a habitand replace chemical treatment [1]. An adaptogenic plant is a plant increasing the body's ability to adapt to different stresses, whatever their origins. This concept is attributed to a Russian toxicologist, Lazarev [13], who sought to define in 1947 the type of plant action such as Ginseng (Panax ginseng C.A. Mey.). An adaptogenicsubstance generally (non-specific) increases the resistance of the organism to diverse stresses that affect it. In traditional Chinese medicine, the notionof "adaptogen" has existed for thousands of years under the concept of "higher tonics” that regulate various functions and increase energy, overall promoting health without treating any specific diseases [15, 16, 17, 18]. Mey.);the Pink stonecrop (Rhodiola rosea L.), and Astragalus with hanging flowers

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