Adaptive Transformations of the Heart Rhythm Regulation and Structure of Behavioral Acts after Glycine Administration

Abstract

The aim of this study was investigation of adaptive alterations in the structure of heart rhythm regulation, the functional levels of memory, and the dynamic characteristics of behavior after the administration of glycine. The heart rhythm variability, using standard statistical techniques of autocorrelation and spectral analysis, was analyzed. Nonsymbolic testing of the visual memory in three visual pattern (7 + 2) exposure modes was also assessed, where the number of correct and incorrect responses and temporal characteristics were calculated. Assessment of the functional state was conducted using dynamic characteristics of the behavioral act in stochastic and deterministic environments and involved measurement of the total response rate, its variance, and differential characteristics of decision making given repeated choices and during choice assessment after successful and unsuccessful trials. Healthy subjects 35–45 years old (7 males and 10 females) were tested before and after sublingual administration of glycine, 0.2 g two times a day, for three weeks. It was found that the sympathetic contribution to the heart rate regulation increased after the administration of glycine and was more pronounced in females. The rate of cognitive processing also significantly increased with an increased plasticity of prognostic self-regulation in all subjects and increased the sensitivity in a stochastic environment in females.