Abstract
The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy pf X-rays in G 0, G 1 and S phase as well as with tritiated water (4 μCi/ml) when the ‘challenge’ dose was given in G 2. There was no AR after prior exposure of the cells in S phase to secondary irradiation from 70 GeV protons. The AR was not observed after preliminary X-irradiation of the lymphocytes in G 0 and G 1 and ‘challenge’ irradiation in G 1. Cells from 6 patients with Down's syndrome were tested. At least 5 of them did not show the AR. The AR is considered to be a phenomenon of the antimutagenic aftereffect.
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