Abstract
At present, optical coherence tomography systems have a limited imaging depth or axial scan range, making diagnosis of large diameter arterial vessels and hollow organs difficult. Adaptive ranging is a feedback technique where image data is utilized to adjust the coherence gate offset and range. In this paper, we demonstrate an adaptive optical coherence tomography system with a 7.0 mm range. By matching the imaging depth to the approximately 1.5 mm penetration depth in tissue, a 3 dB sensitivity improvement over conventional imaging systems with a 3.0 mm imaging depth was realized.
Highlights
Optical Coherence Tomography (OCT) is a cross-sectional optical imaging technique [1] that can be used to obtain images of living human tissues with an axial resolution of several microns
Recent research has demonstrated that OCT is capable of identifying the features of plaques that cause sudden cardiac death [9,10] and dysplasia in Barrett’s esophagus [11]
The imaging range has been expanded by a factor of 2.3, from 3 mm to 7 mm. This method has the advantages that it can be implemented with minimal modifications to existing hardware and performs in real-time
Summary
Optical Coherence Tomography (OCT) is a cross-sectional optical imaging technique [1] that can be used to obtain images of living human tissues with an axial resolution of several microns. Application of OCT in the fields of cardiology, gastroenterology, and ophthalmology is limited by its inability to obtain data when the surface height of the tissue varies by more than the total reference arm scan length or coherence gating range This limitation of current OCT systems prevents imaging of many clinically relevant sites [11,12]. This method adaptively detects the surface of the sample and adjusts the reference delay-scanning offset so that the surface data is always at the top of the image Since this feedback control corrects for surface height variation, and tissue penetration depths do not typically exceed ~1.5 mm, the scan range for a single axial scan may be reduced to 1.5 mm, resulting in a commensurate increase in sensitivity. AR technology operates in real-time and does not require major hardware modifications to conventional OCT systems
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