Abstract
Adaptive deep brain stimulation (aDBS) controlled by local field potentials (LFPs) can improve the clinical benefits induced by conventional DBS (cDBS) in Parkinson's disease (PD). Data obtained in PD patients tested for minutes confirm the superiority of aDBS over cDBS. Testing adaptive approaches for longer time might have however inherent risks. We designed a randomized, double-blind, cross-over clinical trial to compare the amount of charge delivered, the safety and tolerability of 2h aDBS versus 2h cDBS using an external dual (cDBS or aDBS) mode portable device controlled by LFPs. Here we present the preliminary data on 7 patients with PD. Both aDBS and cDBS were administered for 2h consecutively, during which the patient was assessed every 30min, by a blinded investigator. Over the two hours of stimulation there were no treatment related adverse events (severe, moderate and mild) both during aDBS and cDBS. The patients exhibited a significant reduction of dyskinesias ( p t -test, p
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
