Abstract
Paper deals with the performance assessment of adaptive control design of glycemia in type 1 diabetes mellitus (T1DM) subjects. Presented controller consists of model reference adaptive control (MRAC) for basal and heuristic adaptive disturbance rejection for bolus insulin administration. Control algorithm performance is tested via simulation experiments on virtual T1DM subjects, which are generated from individualized T1DM simulator with its parameters introduced to small random changes. Individualization of T1DM model parameters is done by matching the simulator output to T1DM self-monitoring data obtained from continuous glucose monitoring (CGM) device. Simulation results are evaluated by the means of control variability grid analysis.
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