Abstract
"The Chimera was, according to Greek mythology, a monstrous fire-breathing hybrid creature of Lycia in Asia Minor, composed of the parts of more than one animal [...].
Highlights
A world-relevant clinical and environment issue that afflicts millions of people worldwide, hypoxia, i.e., the insufficient supply of oxygen (O2) with respect to demand, constitutes an important source of social and economic distress
The report by Sun et al [3] focuses on autophagy, a cytoprotective mechanism well known to be triggered by hypoxia
The intestinal epithelium represents a paradigm of hypoxia adaptation because it is able to adapt to varying blood flows and, large oxygen gradients due to its localization at the border between the anaerobic lumen and the mesenterial vessels
Summary
A world-relevant clinical and environment issue that afflicts millions of people worldwide, hypoxia, i.e., the insufficient supply of oxygen (O2) with respect to demand, constitutes an important source of social and economic distress. Studies on the molecular response to hypoxia, such as the overexpression of hypoxia-inducible factor-1 (HIF-1), were rewarded with the 2019 Nobel Prize in Physiology and Medicine.
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