Abstract
weakened adaptation reported in neurons from animals with behavioral evidence of tinnitus both increases firing rate and spike train correlations. Our work shows that the biophysical correlates of tinnitus are consistent with the spike train correlates of tinnitus, and that this link is not obvious from past theories linking firing rates and spike train correlations because of the presence of SFA. These results reveal that the biophysical mechanisms giving rise to hyperactivity in tinnitus and other neural pathologies have specific implications for the pairwise statistics and population coding of the affected neurons.
Highlights
In many neural systems, neurons’ firing rates in response to a suprathreshold current decrease with time
Tinnitus is characterized by the persistent perception of a high frequency subjective sound and by an increase in both firing rates and synchrony in many auditory centers [8]
We adapt the results of [10] to the case of spike-driven currents and investigate how spike-frequency adaptation (SFA) affects the relation between firing rates and spike train correlations
Summary
Neurons’ firing rates in response to a suprathreshold current decrease with time. Tinnitus is characterized by the persistent perception of a high frequency subjective sound and by an increase in both firing rates and synchrony in many auditory centers [8].
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