Abstract
The large scale production of inactivated vaccines such as polio and rabies vaccines, using continuous cell lines (CCLs) such as Vero cell line, is still based on a serumcontaining media (SCM), at least for the production of biomass (Duchene et al., (1990)). However, the use of serum during the cell proliferation step of the production process, has several disadvantages such as quality variation among lots and high cost. Furthermore, sera are also a potential source of contamination by virus, mycoplasma, BSE agent, etc. For those reasons, the adaptation of animal cells to grow in serum free media (SFM), allows a more controlled and a less risky bioprocess.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.