Abstract
The purpose of this study was designed to investigate the effects of the intravenous (IV) infusion of propylthiouracil (PTU) on basal and pentagastrin-stimulated gastric acid secretion (GAS), as well as plasma concentrations of gastric inhibitory polypeptide (GIP), and calcium (Ca(superscript 2+)). The polyethylene (PE) tubes were inserted into the esophagus, pylorus, right femoral and jugular veins as luminal and vascular exits respectively in adult male rats. Basal GAS was collected for 45 min before IV infusion of alkaline saline (2 ml/h, control group) or PTU (20 mg/ml/ 300 g BW, experimental group) for 45 min. Infusion of pentagastrin (8 μg/ml/300 g BW) was added for 90 min following infusion of alkaline saline or PTU for an additional 45 min. IV infusion of PTU increased the concentrations of plasma thyroid-stimulating hormone (TSH) and GIP but decreased the level of plasma Ca(superscript 2+) in male rats. Neither the basal nor the pentagastrin-evoked levels of gastric acid secretion were altered by the IV infusion of PTU. These results suggested that the unchanged gastric acid secretion in male rats after IV administration of PTU was at least in part due to an adaption of gastric acid secretion to PTU caused by increased release of GIP and decreased level of plasma calcium.
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