Abstract
Basal and norepinephrine-stimulated (1–100 μM) production of cAMP in rat cerebral cortical slices was determined during chronic ethanol treatment and withdrawal employing a treatment procedure which rapidly produces a hyperactive withdrawal reaction. Basal and norepinephrine-stimulated cAMP production was increased above control values, in slices, following 88 hr of ethanol treatment. After 72 hr of treatment with ethanol, maximal increases in cAMP were found after 16–18 hr of withdrawal. These increases were essentially the same as those found in animals continuously treated for 88 hr. By 24 hr after the removal of ethanol, cAMP production returned to control values. Hyperactive behaviour during the withdrawal period quantitatively paralleled the observed changes in cAMP production. It is proposed that the sensitivity of cerebral cortical adenylate cyclase rapidly adapts subsequent to changes in neuronal input during and after ethanol treatment but that adaptation in the cortical adrenergic system is not a primary event in the development of physical dependence on ethanol.
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