Abstract
This paper describes the use of diverse software tools in cardiovascular applications. These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels. The future of cardiovascular research and the challenges that modellers and clinicians face from validation to clinical uptake are discussed from an end-user perspective.
Highlights
Adaptation and development of software simulation methodologies for cardiovascular engineering: present and future challenges from an end-user perspective
This paper describes the use of diverse software tools in cardiovascular applications
These tools were primarily developed in the field of engineering and the applications presented push the boundaries of the software to address events related to venous and arterial valve closure, exploration of dynamic boundary conditions or the inclusion of multi-scale boundary conditions from protein to organ levels
Summary
Clinicians use a number of different tests to determine the nature of a medical condition and plan a treatment/intervention based upon experience. Other early successes in applying techniques taken from the physical sciences to cardiovascular physiology were engineering analyses of blood flow in arteries using computational fluid dynamics (CFD) These were later coupled with finite-element (FE) analyses to model the structural behaviour of tissue. A coupled system of a St Jude MHV and biologically based boundary conditions of the pumping system is presented (Rafiroiu et al 2008), taking into account fundamental biochemical details of cardiac contraction This kind of approach, which has already been presented in the context of an idealized valve (Dıaz-Zuccarini et al 2007), can provide insight into the underlying biological mechanisms of contraction at different levels, from the protein to the organ. It is essential to be able to ensure that the minimal valve requirements are guaranteed for a specific patient, and can be maintained for a sufficient time as native structures change due to age-related physiological modification or as a response to the treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
