Acylphloroglucinol derivatives from the leaves of Syzygium samarangense and their cytotoxic activities

Abstract

Samarones A–D (1–4), four new acylphloroglucinol derivatives bearing a C17 alkyl side chain, along with five known analogues (5–9), were isolated from the leaves of Syzygium samarangense. Their structures were characterized on the basis of extensive spectroscopic methods including HR-ESI-MS/MS analysis. The cytotoxic activities of compounds 1–3 and 5–9 against HepG2 and MDA-MB-231 cells were also evaluated.