Abstract
The acylation of 2-aminoquinazol-4-one by unsaturated acid chlorides proceeds principally at the exocyclic nitrogen atom and is complicated in the case of acryloyl chloride by a further intramolecular condensation forming 1,2,3,4-tetrahydropyrimido(2,1-b)quinazolin-2,6-dione. A lower acylation temperature using methacryloyl chloride leads to accumulation of 1-methacryloyl-2-aminoquinazol-4-one in the reaction mixture.
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