Acylated triterpenoid saponins from roots of Gypsophila trichotoma

Abstract

Eleven new triterpenoid saponins were isolated from the roots of Gypsophila trichotoma Wend. (Caryophyllaceae) together with one known compounds. The structures were established on the basis of extensive 1D and 2D NMR analysis, completed by analysis of HR-ESI-MS and ESI-MSn. The cytotoxicity of the saponin extract from G. trichotoma was evaluated on a rat alveolar macrophage cell line NR8383 and a human macrophage cell line U937. The synergistic effect of the aminoacyl saponins, previously isolated from G. trichotoma, was tested for its ability to enhance the cytotoxicity of the targeted toxin in HER14 cells.