Abstract
Unsaturated fatty acid amides, 9( Z)-octadecenamide ( 2) and 9( Z),12( Z)-octadecadienamide ( 4) as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT) were isolated from the ethyl acetate extracts of the insect, Mylabris phalerate Pallas, and elucidated by their spectroscopic data analysis. Compounds 2 and 4 inhibited rat liver microsomal ACAT, hACAT-1, and hACAT-2 with IC 50 values of 170, 85, and 63 μM for 2 and of 151, 53, and 45 μM for 4, respectively.
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