Abstract

Abstract—Ethanolamine phosphogylcerides (EPG) of human brain gray and white matter were analyzed for their alk‐1′‐enyl group and fatty acid compositions in sn‐glycerol positions 1 and 2. Gray matter contained more 18:0 (54%) and less 18:1 (24.5%) alk‐1′‐enyl residues than white matter (16% and 57%. Sixty per cent of alk‐1′‐enyl 18.1 in gray matter was the (n‐7), against 71%, in white matter. Both gray and white matter contained small amounts of 18:1 (n‐5) and (n‐3) isomers.The fatty acids in position I of the phosphatidylethanolamines were more saturated than the corresponding alk‐1′‐enyl groups of the plasmalogens. The ratios of monoenoic fatty acid isomers in position 1 were markedly different from those of the corresponding alk‐1′‐enyl groups in gray matter. The fatty acid patterns in position 2 of plasmalogen and phosphatidylethanolamines of white matter were similar except for 22:4(n‐6) which was concentrated in the plasmalogen (16% against 10%, in the phosphatidyl ethanolamine). In gray matter, the same trend was noted.The data suggest that alk‐1′‐enyl residues and the fatty acids in position 1 as well as the fatty acids in position 2 of alk‐1′‐enyl acyl and diacyl type EPG in both gray and white matter are, at least in part, of different provenance.

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