Acutissimanide, a new lignan with antioxidant activity isolated from the bark of Quercus acutissima Carruth

Abstract

Acutissimanide (1), a new lignin, together with 11 known polyphenols (2–12) were isolated from the bark of the deciduous oak tree, Quercus acutissima Carruth. The structure of compound 1 was determined using multidimensional 1H and 13C NMR and mass spectroscopy. The antioxidant properties of compounds 1–12 were investigated using a 1,1-diphenyl-2-picryhydrazyl radical-scavenging assay with compounds 6–11 displaying significant antioxidant activity (EC50 values of 5.2–23.7 μM). Our findings suggest the extracts of Q. acutissima Carruth are a potential source of natural antioxidant additives for use in the food and other allied industries.