Acute-Onset Altitudinal Visual Field Defect Caused by Optic Canal Meningioma

Abstract

Dear Editor, Altitudinal visual field defect (VFD), which involves the loss of visual sensation in the horizontal half of the visual field, is caused mainly by anterior ischemic optic neuropathy (AION),1,2,3 or rarely by compressive neuropathy due to a tumor or aneurysm.4,5 However, acute-onset inferior altitudinal VFD is a hallmark of AION.1,2,3 We observed a patient with a rapidly developed inferior altitudinal VFD due to a small meningioma inside the optic canal, which was almost undetectable in standard imaging studies. A 65-year-old man with hypertension and hyperlipidemia complained of blurred vision persisting over several days. He denied having headache, diplopia, or ocular pain. He had a history of medullary infarction and was taking aspirin, antihypertensive medication, and a statin. With the exception of the old infarction, there were no abnormal findings on axial T2-weighted MRI scans obtained 10 months previously (Supplementary Fig. 1 in the online-only Data Supplement). An ophthalmologic examination revealed decreased visual acuity in the left eye (10/20) compared to the right (16/20). Humphrey perimetry revealed an inferior altitudinal VFD in the left eye, which was more severe on the nasal side than on the temporal side (Fig. 1A). There was no evidence of relative afferent pupillary defects, ptosis, proptosis, or disc swelling, or pallor on funduscopy. Ocular movement, intraocular pressures, and slit-lamp and optical coherence tomography findings were normal. The acute onset and painless monocular visual loss raised a suspicion of AION, leading to a focus on evaluating the patient's vascular etiology. However, there were no abnormal findings on MR angiography (Supplementary Fig. 1 in the online-only Data Supplement). A follow-up visual field test performed 3 weeks later revealed an aggravated altitudinal VFD, especially on the inferior temporal side (Fig. 1A). High-spatial-resolution (2-mm slice thickness) MRI with gadolinium enhancement of the orbit was performed to exclude compressive neuropathy mimicking AION. The results revealed a 1.2-cm meningioma on the posterior part of the left optic canal causing medial displacement and downward compression of the optic nerve (Fig. 1B and C). The patient underwent a frontotemporal craniotomy and resection of the meningioma. The tumor originated from the left side tuberculum sellar and extended into the optic canal. Although he reported a subjective improvement in vision immediately after surgery, the VFD was aggravated on the superior side just before surgery (Fig. 1A). Four months after resection of the tumor, his vision had partially recovered (Fig. 1A). Fig. 1 Serial Humphrey perimetries and high-resolution MRI of compressive optic neuropathy with a monocular inferior altitudinal visual field defect (VFD). A: Initial Humphrey perimetry shows an inferior altitudinal VFD in the left eye that is more severe on ... The main mechanism underlying the visual disturbance in compressive optic neuropathy is secondary disruption of the axoplasmic flow and demyelination of the optic nerve.6 Therefore, the onset of VFD usually progresses slowly. Since the optic nerve delivers visual information received from each of the retinal quadrants to the optic chiasm, the VFD can present in various patterns according to the initial direction of optic nerve compression. In this case the VFD started at the inferonasal area and extended to the inferotemporal area, which can be explained by a medial downward displacement of the optic nerve due to compression from the meningioma (Fig. 1D). The VFD was rapid and severe due to the meningioma being located on the optic canal and the diagnosis delay. Another possible mechanism is ischemia caused by vascular compression. Ischemic symptoms usually present as posterior ischemic optic neuropathy (PION) with compression of the collateral branches from the ophthalmic artery in the optic canal.7 However, ischemia is unlikely to be the main mechanism in this case for two reasons: 1) an altitudinal VFD is relatively rare in PION7 and 2) in this case the VFD worsened according to the direction of nerve compression and improved following surgical resection. Other features associated with compressive optic neuropathy were absent in this case, which may be due to the smallness of the tumor. Optic nerve meningioma arising within the optic canal is rare.8 These tumors are usually extremely small despite causing significant visual disturbance and can easily be overlooked on routine MRI. Furthermore, they may not have any orbital signs, and may present with a normal-appearing optic disc.8 Therefore, it is necessary to consider compressive optic neuropathy when a patient presents with an altitudinal VFD, even in the absence of other symptoms.