Abstract
Background: Cholewin Plus tablets are used for the treatment of hyperlipidemia and coronary artery disease. Aim: The aim of this study was to determine acute oral toxicity of Cholewin Plus tablet in vivo in Wistar rats. Materials and Methods Rats were orally administrated single dose of 5, 300, and 2000 mg/kg Cholewin Plus tablet and the controlled group received vehicle only orally. There were five rats in each group. All animals were killed after 14 days of treatment and histopathology was performed. A total of four parameters were observed throughout the study: cage side observation, the effect on body weight, the effect on hematological parameter, and histopathology. Result: No mortality and morbidity were noted after 14 days of treatment. In general, behavior, food and water consumption, hematological studies, and histopathology showed no significant changes. Conclusion: The oral administration of Cholewin Plus tablet did not show any toxic effect on the animal at the dose of 2000 mg/kg body weight. Therefore, it is a safe remedy for human use.
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